New antimicrobial peptide kills drug-resistant pathogens without detectable resistance
نویسندگان
چکیده
منابع مشابه
A new antibiotic kills pathogens without detectable resistance
Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were produced by screening soil microorganisms, but this limited resource of cultivable bacteria was overmined by the 1960s. Synthetic approaches to produce antibiotics have been unable to replace this platform. Uncultured bacteriamake up appr...
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Boromycin is a boron-containing polyether macrolide antibiotic isolated from Streptomyces antibioticus. It was shown to be active against Gram positive bacteria and to act as an ionophore for potassium ions. The antibiotic is ineffective against Gram negative bacteria where the outer membrane appears to block access of the molecule to the cytoplasmic membrane. Here we asked whether boromycin is...
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In the present study, aqueous and solvent extracts of leaves collected from nine mangrove plants were screened against Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Staphylococcus aureus (VRSA) and Extended spectrum beta lactamase (ESBL) strains. Out of nine mangrove plants Avicennia sp., Rhizophora sp., Ceriops decandra and Thillai species showed antimicrobial activi...
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Cationic antimicrobial peptides (CAMPs) are critical front line contributors to host defense against invasive bacterial infection. These immune factors have direct killing activity toward microbes, but many pathogens are able to resist their effects. Group A Streptococcus, group B Streptococcus and Streptococcus pneumoniae are among the most common pathogens of humans and display a variety of p...
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Doshi highlights the danger of speeding new antibiotics to market without adequate testing. However, it is dangerous to question the threat from antimicrobial resistance, and such questions must not detract from the urgent need for new antimicrobial agents. The reduction in mortality from infections worldwide between 1990 and 2013 highlighted by the Global Burden of Disease study coincides with...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2018
ISSN: 1949-2553
DOI: 10.18632/oncotarget.24582